Fig. 1
From: The Fas Counterattack: A Molecular Mechanism of Tumor Immune Privilege
The Fas counterattack
The cancer cell resists FasL-mediated T cell cytotoxicity due to up-(↑) or down-(↓) regulation or mutation (X) of genes that regulate the Fas apoptotic pathway, or to expression of soluble FasR (SolFasR). The cancer cell counterattacks by expressing its own FasL, which rapidly induces apoptosis in activated T cells.