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Fig. 3 | Molecular Medicine

Fig. 3

From: Suberoylanilide Hydroxamic Acid as a Potential Therapeutic Agent for Human Breast Cancer Treatment

Fig. 3

SAHA induces cell cycle arrest and apoptosis in human breast cancer cells. MCF7, MDA-MB-231, and MDA-MB-435 cells were treated with dimethylsulfoxide (DMSO) alone, or suberoylanilide hydroxamic acid (SAHA) at 4 ยตM for 24 hr or 48 hr, and then analyzed for cell cycle distribution by flow cytometry. Shown are DNA histograms. The apoptotic cells (Apo) in the sub-G1 population are indicated by an arrow.

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