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Fig. 5 | Molecular Medicine

Fig. 5

From: Intranasal Immunization of Mice with CpG DNA Induces Strong Systemic and Mucosal Responses That Are Influenced by Other Mucosal Adjuvants and Antigen Distribution

Fig. 5

HBsAg-specific T cell proliferative responses after intranasal (IN) immunization (small volume). BALB/c mice (n = 5) were immunized by IN inhalation of 10 µg of HBsAg alone (none) or with 1, 10, or 50 µg cholera toxin (CT) and/or CpG-containing oligodeoxynucleotides (CpG) as adjuvants in a volume of 20 µl. Mice were boosted at 4 and 8 weeks. Each circle represents the Ag-specific T cell proliferative responses expressed as counts per minute (cpm) for individual mice in splenocytes isolated 4 weeks after third and final immunization. HBsAg, purified hepatitis B surface antigen.

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Molecular Medicine

ISSN: 1528-3658