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Fig. 12 | Molecular Medicine

Fig. 12

From: The Molecular Mechanism of the Insulin-mimetic/sensitizing Activity of the Antidiabetic Sulfonylurea Drug Amaryl

Fig. 12

Hypothetical model for insulin-mimetic metabolic signaling by Amaryl via caveolae/DIGs. (See text for details). DIG, detergent-insoluble glycolipid-enriched rafts; non RTK, dual acylated non-receptor tyrosine kinase; GPI-PLC, glycosyl-phosphatidylinositol-phospholipase C; IRS, insulin receptor substrate; son-of-sevenless (SOS), MAPK and extracellular signal related kinase kinase (MEK), MAPK, mitogen-activated protein kinase; Grb 2, growth factor receptor-bound protein 2; GSK-3β, glycogen synthase kinase 3β GLUT, 4 glucose transporter isoforms; 4 SHC.

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Molecular Medicine

ISSN: 1528-3658