Fig. 3

Hypthetical model for the open and glibenclamide-induced closed states of a K_ATP. [See text for details (18)]. In the glibenclamide-bound state (right section), interaction of the inhibitory ATP with subunit KIR6.2 is indicated; whereas, ATP and Mg²⁺ADP (the interaction of which with the nucleotide-binding folds (NBFs) of sulfonylurea receptor protein for glibenclamide (SUR1) in the open state is shown on the left section) are leaving NBF-1 and NBF-2, respectively, of SUR1. TMD, transmembrane domains.