Fig. 8

Domain organization of caveolin. Structures of the (wild type and mutant) caveolin-scaffolding domains of caveolin isoforms 1–3 and (wild type and mutant) caveolin binding domains of pp59^Lyn, and the consensus sequence derived for the caveolin binding domain of signaling proteins are presented (see text for details). The fatty acyl side chains of the carboxy-terminal cytosolic domain of caveolin, which presumably is anchored at the caveolar plasma membrane, are indicated. TM, membrane-interacting region of caveolin.