Fig. 3
From: Involvement of the Endothelin System in Experimental Critical Hind Limb Ischemia
Plasma and tissue endothelin-1 (ET-1) concentration. (A) Plasma levels of ET-1 before induction of ischemia (H0), 5hr (H5), and 1, 5 and 14 days (D1, D5 and D14, respectively) after surgery in control animals (—) and in bosentan-treated animals (…….). *, p < 0.05 in comparison with D1. **, p < 0.001 in comparison with other times. (B) Endothelin-1 concentrations in ischemic (I) and sham-operated (S) muscles at 5hr (H5) and day 5 (D5). Results are expressed as picograms of endothelin-1 per mg of total proteins (pg/mg prot). (n = 5 per group. Mean ± standard error of the mean, SEM).*, p < 0.05, ischemic vs. sham.