Fig. 5
From: Involvement of the Endothelin System in Experimental Critical Hind Limb Ischemia
Effects of endothelin antagonists on blood flow. (A) Residual blood flow (% of ipsilateral pre-surgery values) observed in the ischemic (I) and sham operated (S) hind limbs in control, Bosentan-treated, and LU 135252-treated rats immediately after surgery (the individual values for each of the three muscles are pooled using an ANOVA for repeated measures). Results expressed as mean ± standard error of the mean, SEM.*, p < 0.05, in comparison with other groups. (B) Residual blood flow (% of contralateral hind limb values) observed immediately (D0) and 14 days (D14) after induction of ischemia (the individual values for each of the three muscles are pooled using an ANOVA for repeated measures). Results expressed as mean ± standard error of the mean, SEM.***, p < 0.001, in comparison with control group.