Table 1 Estradiol specific receptor (ER) status in human breast cancer biopsy specimens
From: A Therapeutic Target for Hormone-independent Estrogen Receptor-positive Breast Cancers
Immunodetection | DNA-Binding | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Tissue # | Patient # | Class | Age (yrs) | Tumor/Stage | 3H-E2 Binding | ER−Ab | PR-Ab | 32P-ERE | 32P-PRE |
1 | 6 | 1 | 51 | Inv. Duct/II | + | + | + | + | + |
2 | 7 | 1 | 78 | Inv. Duct/II | + | + | + | + | + |
3 | 9 | 1 | 51 | Inv. Duct/II | + | + | + | + | + |
4 | 10 | 1 | 41 | Inv. Duct/I | + | + | + | + | + |
5 | 12 | 1 | 53 | Inv. Duct/I | + | + | + | + | + |
6 | 14 | 1 | 44 | Inv. Lob/I | + | + | + | + | + |
7 | 1 | 2 | 58 | DCIS/I | − | − | − | − | − |
8 | 2 | 2 | 36 | Inv. Duct/II | − | − | − | − | − |
9 | 4 | 2 | 76 | Inv. Duct/II | − | − | − | − | − |
10 | 8 | 2 | 48 | Inv. Duct/II | − | − | − | − | − |
11 | 15 | 2 | 59 | Adenocarcinoma | − | − | − | − | − |
Metastatic/IV | |||||||||
12 | 3 | 3 | 43 | Inv. Duct/I | + | + | + | − | − |
13 | 11 | 3 | 72 | Inv. Duct/IV | + | + | + | − | − |
14 | 5 | 4 | 80 | Inv. Duct/II | − | + | + | + | + |
15 | 13 | 4 | 55 | Inv. Duct/II | − | + | + | + | + |
Cell Lines | Class | ||||||||
T47D | 1 | + | + | + | + | + | |||
MDA-MB231 | 2 | − | − | − | − | − | |||
None | 3 | ||||||||
21PT | 4 | − | + | + | + | + | |||