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Fig. 6 | Molecular Medicine

Fig. 6

From: Proinflammatory Cytokine Expression Contributes to Brain Injury Provoked By Chronic Monocyte Activation

Fig. 6

Expression of TNFα (A–D) and TNFR1 (E–G) immunoreactivity in the brain. (A) TNFα immunoreactivity after LPS administration in a BCG-primed rat. Note staining of neurons, small round cells on the cortex (star), in inset staining of monocytes in an intraparenchymal blood vessel (arrow). C preadsoption of the signal in A, with incubation of the antibody with a 50x excess concentration of recombinant rat TNFα. D depicts reappearance of the staining when the recombinant rat TNFα was reacted with TNFbp prior to the antibody preabsorption. (B) TNFα immunoreactivity (star) in the brain of a rat treated with TNFbp. (E) TNFR1 immunoreactivity in cortex of a BCG + LPS-treated rat (arrows). (F) TNFR1 staining of infiltrating cells (arrows) and granular perivascular staining (star) in a rat treated with TNFbp before LPS. (G) Preadsorption of the signal in F with 100x excess of the control peptide. In all, scale bar = 50 µm.

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Molecular Medicine

ISSN: 1528-3658