Table 1 Prevalence of ADH2, ADH3, Cyp2E1 and TNF α alleles in the populations of heavy drinkers from the towns of Cormons and Campogalliano. HD: heavy drinker individuals
Alleles | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N. of Alleles | ADH2-Exons III, IX | ADH3-Exon VIII | CYP2E1-Intron VI | CYP2E1-Promoter | TNF(−238) | TNF(−308) | ||||||||
ADH2*1 | ADH2*2 | ADH2*3 | ADH3*1 | ADH3*2 | MSPI1 | MAPI2 | C1 | C2 | G | A | 1 | 2 | ||
CORMONS | 158 | |||||||||||||
Healthy HD | 88 | 88(1) | 0(0) | 0(0) | 54(0.61) | 34(0.39) | 87(0.99) | 1(0.01) | 87(0.99) | 1(0.01) | 83(0.94) | 5(0.06) | 69(0.78) | 19(0.22)d |
HD with ALD | 70 | 70(1) | 0(0) | 0(0) | 33(0.47) | 37(0.53) | 69(0.99) | 1(0.01) | 70(1) | 0(0) | 67(0.96) | 3(0.04) | 63(0.90) | 7(0.10) |
HD with cirrhosis | 18 | 18(1) | 0(0) | 0(0) | 9(0.50) | 9(0.50) | 18(1) | 0(0) | 18(1) | 0(0) | 18(1) | 0(0) | 15(0.83) | 3(0.17) |
CAMPOGALLIANO | 158 | |||||||||||||
Healthy HD | 96 | 94(0.98) | 2(0.02) | 0(0) | 61(0.64) | 35(0.36) | 95(0.99) | 1(0.01) | 90(0.94) | 6(0.06) | 93(0.97) | 3(0.03) | 85(0.88) | 11(0.12) |
HD with ALD | 62 | 62(1) | 0(0) | 0(0) | 43(0.69) | 19(0.31) | 61(0.98) | 1(0.02) | 50(0.81) | 12(0.19)a | 57(0.92) | 5(0.08) | 56(0.90) | 6(0.10) |
HD with cirrhosis | 12 | 12(1) | 0(0) | 0(0) | 7(0.58) | 5(0.42) | 11(0.92) | 1(0.08) | 8(0.67) | 4(0.33)b | 12(1) | 0(0) | 10(0.83) | 2(0.17) |
TOTAL | 316 | |||||||||||||
Healthy HD | 184 | 182(0.99) | 2(0.01) | 0(0) | 115(0.62) | 69(0.38) | 182(0.99) | 2(0.01) | 177(0.96) | 7(0.04) | 176(0.96) | 8(0.04) | 154(0.84) | 30(0.14) |
HD With ALD | 132 | 132(1) | 0(0) | 0(0) | 76(0.58) | 56(0.42) | 130(0.98) | 2(0.02) | 120(0.91) | 12(0.09)c | 124(0.94) | 8(0.06) | 119(0.90) | 13(0.10) |
HD with cirrhosis | 30 | 30(1) | 0(0) | 0(0) | 16(0.53) | 14(0.47) | 29(0.97) | 1(0.03) | 26(0.87) | 4(0.13) | 30(1) | 0(0) | 25(0.83) | 5(0.17) |