Table 3 Prevalence of ADH3, Cyp2E1 and TNF α genotypes in the populations of heavy drinkers from the towns of Cormons and Campogalliano
Genotypes | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N. of Cases | ADH3-Exon VIII | CYP2E1-Promoter | TNFα-Promoter (−238) | TNFα-Promoter(−308) | |||||||||
ADH3*1/1 | ADH3*1/2 | ADH3*2/2 | C1/C1 | C1/C2 | C2/C2 | G/G | A/G | A/A | 1/1 | 1/2 | 2/2 | ||
CORMONS | 79 | ||||||||||||
Healthy individuals | 44 | 13(29%) | 28(64%) | 3(7%) | 43(98%) | 1(2%) | 0(0%) | 39(89%) | 5(11%) | 0(0%) | 29(66%) | 11(25%) | 4(9%) |
Patients with ALD | 35 | 9(26%) | 15(43%) | 11(31%)a | 35(100%) | 0(0%) | 0(0%) | 32(91%) | 3(9%) | 0(0%) | 29(83%) | 5(14%) | 1(3%) |
Patients with cirrhosis | 9 | 3(33%) | 3(33%) | 3(33%) | 9(100%) | 0(0%) | 0(0%) | 9(100%) | 0(0%) | 0(0%) | 7(78%) | 1(11%) | 1(11%) |
CAMPOGALLIANO | 79 | ||||||||||||
Healthy individuals | 48 | 18(38%) | 25(52%) | 5(10%) | 42(88%) | 6(12%) | 0(0%) | 45(94%) | 3(6%) | 0(0%) | 39(81%) | 7(15%) | 2(4%) |
Patients with ALD | 31 | 16(52%) | 11(35%) | 4(13%) | 20(64%) | 10(32%)d | 1(4%) | 26(84%) | 5(16%) | 0(0%) | 26(84%) | 4(13%) | 1(3%) |
Patients with cirrhosis | 6 | 3(50%) | 1(17%) | 2(33%) | 2(33%) | 4(67%)e | 0(0%) | 6(100%) | 0(0%) | 0(0%) | 4(67%) | 2(33%) | 0(0%) |
TOTAL | 158 | ||||||||||||
Healthy individuals | 92 | 31(34%) | 53(58%) | 8(9%) | 85(92%) | 7(8%) | 0(0%) | 84(91%) | 8(9%) | 0(%) | 68(74%) | 18(20%) | 6(7%) |
Patients with ALD | 66 | 25(38%) | 26(39%) | 15(23%)b | 55(83%) | 10(15%) | 1(2%) | 58(88%) | 8(12%) | 0(0%) | 55(83%) | 9(14%) | 2(3%) |
Patients with cirrhosis | 15 | 6(40%) | 4(27%) | 5(33%)c | 11(73%) | 4(27%)f | 0(0%) | 15(100%) | 0(0%) | 0(0%) | 11(73%) | 3(20%) | 1(7%) |