Table 1 Status of tumor suppressor gene/oncogene/cell-cycle regulation genes (p53, RB, p16, ras) in normal and cancer cell types used in this study and their correlation with Ad-mda7 killing
From: Melanoma Differentiation Associated Gene-7 (mda-7): A Novel Anti-Tumor Gene for Cancer Gene Therapy
Cell Type | Ad-mda7 Killing | p53 | RB | Ras | p16 |
|---|---|---|---|---|---|
NORMAL | Â | Â | Â | Â | Â |
Hmec | − | wt | wt | wt | wt |
MJ90 fibroblasts | − | wt | wt | wt | wt |
HuVEC | − | wt | wt | wt | wt |
BREAST | Â | Â | Â | Â | Â |
T47D | + | Mut | — | wt | — |
MCF-7 | + | wt | — | wt | — |
LUNG | Â | Â | Â | Â | Â |
H1299 | + | Null | wt | Mut | Neg |
A549 | + | wt | — | Mut | Neg |
H460 | + | wt | wt | Mut | Del |
COLORECTAL | Â | Â | Â | Â | Â |
SW620 | + | Mut | — | Mut | Neg |
HCT116 | + | wt | — | Mut | Neg |