Aberration of FHIT Gene is Associated with Increased Tumor Proliferation and Decreased Apoptosis—Clinical Evidence in Lung and Head and Neck Carcinomas

Table 1 FHIT gene status, p21 expression, and [ ³ H]-thymidie labeling in patients with synchronous displasia, CIS, and HNSCC.

Patient No.	Normal Adjacent to Lesion			Dysplasia			CIS			Cancer
Patient No.	FHIT	p21	³H-[Thy]	FHIT	p21	³H-[Thy]	FHIT	p21	³H-[Thy]	FHIT	p21	³H-[Thy]
1	N	3	1.7	N	1	2.3	N	3	1.9	At + Em (8)	1	9.7
2	N	3	2.7	At + Em (4–8)	0	4.3	At + Em (4–8)	0	5.4	At + Em (4–8)	0	5.5
3	At + Em (4–8)	0	2.0	At + Em (4–8)	0	3.8	At + Em (4–8)	0	2.1	At + Em (4–8)	1	4.5
4	At + Em (8)	1	5.9	At + Em (8)	1	4.2	At + Em (8)	0	3.3	At + Em (8)	0	3.8
5	N	2	0.8	N	2	1.5	N	1	4.0	N	0	4.9
6	N	2	1.9	N	2	ND	N	ND	4.0	N	0	3.9
7	At + Em (5–7)	1	4.4	At + Em (5–7)	0	3.0	At + Em (5–7)	1	7.9	At + Em (5–7)	0	10.1
8	N	ND	ND	N	ND	ND	At + Em (4–8)	ND	12.7	At + Em (4–8)	0	14.1
9	N	3	2.9	N	2	ND	N	1	3.4	At + Em (4–8)	1	ND
10	N	3	ND	N	2	7.6	At + Em (8)	0	7.0	At + Em (8)	0	10.8
11	N	2	ND	At + Em (8)	0	ND	At + Em (8)	1	ND	At + Em (8)	1	ND
12	N	3	1.0	N	3	1.9	N	ND	4.1	N	2	7.1

N, normal; ND, not determined; At, aberrant transcript; Em, exon missing (number of exon); [³H]-Thy, [³H]-thymidie labeling × 10³; CIS, carcinoma in situ; HNSCC, squamous cell carcinoma of the head and neck.

ISSN: 1528-3658