Aberration of FHIT Gene is Associated with Increased Tumor Proliferation and Decreased Apoptosis—Clinical Evidence in Lung and Head and Neck Carcinomas

Table 2 FHIT gene status, smoking status, tumor stage, p21 expression, [³H]-thymidie labeling, and apoptosis in lung cancer.

Case No.	Lung Cancer Type	S/A Status	Stage	FHIT Status	p21	[³H]-Thy	Apoptosis (%)
1	Adenocarcinoma	S	T2N0M0	At + Em (8)	0	4.5	47
2	Adenocarcinoma	S	—	At + Em (8)	0	3.9	22
3	Adenocarcinoma	S	T2N2M0	NAt + Em (4–8)	0	17.1	11
4	Adenocarcinoma	S	T3N2M2	NAt + Em (5–7)	1	10.0	15
5	Adenocarcinoma	S	T2N0M0	N	3	2.0	59
6	Squamous cell	S	T4N3M1	N	3	1.7	67
7	Squamous cell	NK	T3N2M1	NAt + Em (8)	1	5.7	22
8	Squamous cell	S	T3N2M1	NAt + Em (5–7)	2	7.3	22
9	Squamous cell	S	T4N3M1	NAt + Em (8)	0	9.4	18
10	Squamous cell	S	T3N2M0	NAt + Em (8)	0	9.7	5
11	Squamous cell	S	T2N2M0	NAt + Em (8)	1	4.9	14
12	Squamous cell	S	T2N0M0	At + Em (4–7)	0	7.3	29
13	Squamous cell	S	T2N0M0	At + Em (4–7)	1	9.9	12
14	Squamous cell	S	T3N3M1	At + Em (4–7)	1	4.6	17
15	Squamous cell	S	T2N0M0	NAt + Em (8)	0	9.0	21
16	Squamous cell	S	T3N2M1	NAt + Em (8)	0	7.6	20
17	Large cell	S	T3N2M0	At + Em (5–7)	1	5.5	15
18	Large cell	NK	—	NAt + Em (4–8)	1	7.3	ND
19	Large cell	S	T2N0M0	NAt + Em (4–8)	0	7.8	ND
20	Large cell	S	T3N3M1	NAt + Em (4–8)	0	3.9	27

N, normal; ND, not determined; At, aberrant transcript; Em, exon missing (number of exon); [³H]-Thy, [³H]-thymidie labeling (×10³); S; smoking history; NK, not known.

ISSN: 1528-3658