Aberration of FHIT Gene is Associated with Increased Tumor Proliferation and Decreased Apoptosis—Clinical Evidence in Lung and Head and Neck Carcinomas

Table 4 FHIT gene status, smoking and alcohol status, tumor stage, p21 expression, [ ³ H]-thymidie labeling, and apoptosis in HNSCC.

Case No.	Tumor Site	S/A Status	Stage	FHIT Status	p21	[³H]-Thy	Apoptosis(%)
1	Tongue	SA	T₂N_2bM_x	At + Em (8)	1	8.6	7
2	Tongue	S	T₂N₀M_X	At + Em (8)	2	12.5	12
3	Tongue	S	T₃N_2bM_x	At + Em (4–8)	1	7.8	25
4	Tongue	SA	T₂N₀M_X	N	3	1.5	63
5	Tongue	SA	T₁N₀M_X	At + Em (4–8)	1	19.0	19
6	Tongue	SA	T₁N₁M_X	At + Em (5–7)	1	7.5	30
7	Tongue	SA	T₂N₀M_X	N	3	2.0	58
8	Alveolar ridge	S	T₂N₀M_X	At + Em (8)	0	12.7	14
9	Alveolar ridge	S	T₂N₀M_X	At + Em (4)	1	ND	31
10	Alveolar ridge	SA	T₁N₀M_X	At + Em (5–8)	2	19.5	16
11	Alveolar ridge	A	T₁N₁M_X	N	3	2.5	65
12	Alveolar ridge	S	T₂N₂M_X	N	1	3.5	49
13	Alveolar ridge	SA	T₂N₀M_X	At + Em (4–8)	1	7.7	17
14	Tonsil	—	T₃N₁M_X	At + Em (8)	1	18.0	23
15	Tonsil	A	T₄N_2bM_X	At + Em (8)	1	9.9	29
16	Tonsil	SA	T₂N₁M_X	At + Em (4–8)	1	ND	11
17	Tonsil	SA	T₄N_2bM_X	N	3	2.5	70
18	Tonsil	—	T₂N₀M_X	N	3	1.7	59
19	Retromolar	SA	T₁N₀M_X	N	2	4.5	76
20	Retromolar	SA	T₂N_2bM_X	At + Em (8)	1	2.1	18
21	Retromolar	S	T₁N₀M_X	At + Em (5–7)	1	10.9	27
22	Retromolar	SA	T₂N_2bM_X	At + Em (4–8)	1	ND	14
23	Retromolar	S	T₂N_2bM_X	At + Em (8)	1	9.1	23

N, normal; ND, not determined; At, aberrant transcript; Em, exon missing (number of exon); [³H]-Thy, [³H]-thymidie labeling (×10³); S, smoking; A, alcohol.

ISSN: 1528-3658