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Table 1 Kinetic parameters of V6 cDNA encoded vasopressin V1-type receptor.

From: Identification of a Novel V1-type AVP Receptor Based on the Molecular Recognition Theory

 

EC50 (nM)

Ki (nM)

Bmax (fmols 10−6 cells)

45Ca2+ efflux

0.050 ± 0.007

  

IP3 formation

0.050 ± 0.006

  

AVP

 

6.0 ± 0.9

8.4 ± 0.7

V1 antagonista

 

250.0 ± 18.0

 

V1/V2 antagonistb

 

600.0 ± 34.0

 

V2 agonist (DVDAVP)c

 

600.0 ± 43.0

 
  1. a[d(CH2)5, Tyr(Me)]-AVP.
  2. b[d(CH2)5, D-Ile2, Ile4]-AVP.
  3. cDVDAVP[1-deamino, Val4, D-Arg8]-AVP.
  4. Affinity constants (± error) were determined by Scatchard analysis (KELL for Windows, BIOSOFT) of data presented in Figure 3.
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Molecular Medicine

ISSN: 1528-3658