Fig. 7

Ang-1 and Ang-2 mRNA levels in placentae of woman with established preeclampsia (n = 9) as compared to normotensive woman matched for gestational age detected by semiquantitative RT-PCR. (A) Autoradiography. (B) Ang-1 mRNA levels had no statistical difference in preeclamptic placentae compared to matched samples from women who remained normotensive (normal group, median = 0.4575, range 0.8020–0.1020; preeclamptic group, median = 0.2825, range 0.7250–0.0040; Wilcoxon signed rank test, n = 9, p = 0.3828). (C) Ang-2 mRNA levels were reduced in preeclampsia (normal group, median = 0.3280, range 0.5560–0.1630; preeclamptic group, median = 0.1870, range 0.3690–0.0020; Wilcoxon signed rank test, n = 9, p = 0.008). The mRNA levels were always lower in the preeclampsia group than those in the matched control. ♦ normal pregnancy; * preeclampsia. Gestational ages in weeks are as indicated.