Table 3 VH gene segment usage in IgM heavy chains from RF + and RF − B cells
Donors | Specificity | No. of Clones | Frequency (%) | p Patients Versus Normal Controls | |||||
|---|---|---|---|---|---|---|---|---|---|
VH1 | VH2 | VH3 | VH4 | VH5 | VH6 | ||||
Normal controls | RF− | 127 | 30.7 | 3.9 | 42.5 | 8.7 | 12.6 | 1.6 | N/A |
RA patients | RF− | 113 | 23.0 | 3.5 | 50.4 | 16.8 | 4.4 | 1.8 | NS |
RF+ | 60 | 13.3 | 1.7 | 76.7 | 3.3 | 3.3 | 1.7 | 0.001 | |
pSS patients | RF− | 82 | 24.4 | 2.4 | 43.9 | 12.2 | 11.0 | 6.1 | NS |
RF+ | 47 | 21.3 | 2.1 | 61.7 | 6.4 | 4.3 | 4.3 | NS | |