Table 4 Usage of VH3 gene segment subtypes in IgM heavy chains from RF + and RF − B cells
Frequency (%) | ||||||||
|---|---|---|---|---|---|---|---|---|
Donors | Specificity | No. of Clones | V3-23 | V3-30 | V3-21 | V3-15 | Others | p Patients Versus Normal Controls |
Normal controls | RF− | 33 | 39.4 | 27.3 | 0.0 | 3.0 | 30.3 | N/A |
RA patients | RF− | 34 | 17.6 | 20.6 | 5.9 | 8.8 | 47.1 | NS |
RF+ | 31 | 16.1 | 13.0 | 19.4 | 16.1 | 35.5 | 0.007 | |
pSS patients | RF− | 27 | 18.5 | 25.9 | 7.7 | 3.7 | 44.4 | NS |
RF+ | 27 | 11.1 | 37.0 | 14.8 | 0.0 | 37.0 | 0.03 | |