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Fig. 7 | Molecular Medicine

Fig. 7

From: Localization of Macrophage Migration Inhibitory Factor (MIF) to Secretory Granules within the Corticotrophic and Thyrotrophic Cells of the Pituitary Gland

Fig. 7

Relative changes observed in MIF-containing granules in corticotrophic and thyrotrophic cells 16 hr after endotoxin administration

Gold-labeled granules were quantified by stereoscopic microscopy of electron micrographs as described in Materials and Methods. Seven pituitaries were analyzed for each time point. The relative percentage change in MIF staining was calculated by the formula: (MIF-positive gold-labeled granules/total gold-labeled granules) × 100. In corticotrophic cells, the total number of gold-labeled granules observed was 200.9 ± 101.3 and 163.5 ± 81.9 at 0 and 16 hr respectively (p = NS), and in thyrotrophic cells: 212.6 ± 114.7 and 244.7 ± 104.2 at 0 and 16 hr respectively (p = NS). *p < 0.05 as analyzed by the Mann-Whitney U test.

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