Fig. 3.

TUNEL-positive cells are seen in pathological hallmarks of SIV infection of the CNS

High-power view of macaque CNS infected with neurovirulent SIV shows TUNEL-positive cells amidst microglial nodules (A). Note that occasional cells with morphological appearance of neurons are TUNEL positive (arrow). Blood vessels are frequently TUNEL positive, usually in association with perivascular cuffing (B). Multinucleated giant cells are usually TUNEL positive (D, closed arrow) or are found closely associated with other TUNEL-positive cells (C and D, open arrows). Scale bars = 100 µm.