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Fig. 5 | Molecular Medicine

Fig. 5

From: Oligodeoxynucleotides Enhance Lipopolysaccharide-Stimulated Synthesis of Tumor Necrosis Factor: Dependence on Phosphorothioate Modification and Reversal by Heparin

Fig. 5

Structural similarities between the polyanions phosphorothioate-deoxyribonucleic acid and heparin

In phosphorothioate-modified oligodeoxynucleic acid, one free oxygen atom of the phosphate is replaced by a sulfur atom, providing increased stability against nucleases. Base, the linkage to one of the bases adenosine, guanosine, cytosine, and thymidin. For heparin one of several possible sulfated disaccharides of the polysaccharide chain is shown. Both heparin and phosphorothioate-deoxyribonucleic acid represent polyanions. Groups of the molecules that are negatively charged under cell culture conditions are indicated with bold letters.

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Molecular Medicine

ISSN: 1528-3658