Table 2 Effect of thalidomide and analogs on serum cytokine levels in LPS treated mice

LPS (5 mg/kg) +:

None (control)

—

4.5 ± 1.5

19.9 ± 5.1

Thalidomide

1

2.2 ± 0.7^a

25.6 ± 5.6

10

2.1 ± 0.8^a

25.3 ± 5.6

100

1.7 ± 0.5^a

32.4 ± 4.8^a

CC-1069

1

3.1 ± 1.0

25.7 ± 2.1

10

1.5 ± 0.2^a

28.7 ± 4.1^a

100

0.6 ± 0.3^a

44.8 ± 5.6^a

CC-1104

1

4.9 ± 0.8

13.0 ± 0.3

10

3.2 ± 0.3

16.7 ± 3.8

100

1.9 ± 0.4^a

17.9 ± 2.3

CC-1115

1

2.7 ± 0.9

26.6 ± 2.8

10

2.7 ± 0.4

29.9 ± 2.5^a

100

1.6 ± 0.4^a

32.4 ± 2.4^a