Fig. 1
From: Cell Cycle Exit: Growth Arrest, Apoptosis, and Tumor Suppression Revisited
Model of molecular functions involving histone acetylases and deacetylases. p300/CBP can be recruited to promoter elements by interaction with various sequence-specific transcriptional activators or repressors. P/CAF could also be recruited onto the specific promoters through interaction with p300/CBP, then acetylate (A) or deacetylate (B) histones in a promoter-specific manner. Targeted histone acetylation or deacetylation could contribute to promoter activation or repression by changing the chromatin structure. [Remodeled with permission from Yang et al., 19967.]