Fig. 1

Analyses of Cγ+ transcripts from synovial tissue of patient with long-standing RA. (A) Utilization of V_H gene segment families. Proportion of gene segments derived from the V_H1 through V_H7 families as assessed by sequence analysis or Southern blot hybridization with family-specific probes from RA synovium (black bars, n = 67 clones) compared with transcripts from an IgG cDNA library from normal adult PBLs [white bars, n = 29 clones (47)]. (B) Relative proportions of expressed J_H gene segments in RA synovial clones (black bars, n = 63 clones) and normal adult PBLs [white bars, n = 97 clones (46)].