Table 1 Germline derivation of V _H sequences expressed in the synovial tissue of a patient with longstanding rheumatoid arthritis

V₁₋₆₉ (hv1263, 51p1, DP-10)

S3P11

1

Complete

81

RF, FL, CLL

4,5,30–33

S5P3^a

1

Complete

91

S8P10^a

1

Complete

95

S11P17

1

Complete

88

S15P6

1

Complete

93

S17P4

1

Complete

91

S1-6P1

1

Complete

92

V₁₋₄₆ (21-2, DP-7)

S1P9^a

1

Complete

92

RF

4,5,9,34

S5P13

1

Complete

89

S15P4

1

CDR2

91

DP-3

S1P19

1

FR 2

95

—

4

V₁₋₁₈ (DP-14)

S2P10^a

1

FR 1

94

—

4,5

S15P1

1

FR 1

95

—

4,5

V_1−03b(DP-25)

S2P13

1

Complete

95

Anti-DNA

3,35,36

S19P2

1

CDR2

93

V1₋₀₂ (20p3)

S6P26^a

1

FR 3

88

RF, FL

3,30,37

V₂₋₅ (DP-76)

S14P1

2

Complete

91

RF, CLL

5,38,39

V₃₋₁₁ (DP-35)

S1P15^a

3

Complete

95

—

4,5

S4P12^b

3

Complete

85

S5P14^a,b

3

Complete

82

S6P15

3

Complete

80

S7P5

3

Complete

94

S9P16^a

3

Complete

93

S11P9

3

CDR2

83

S17P1

3

CDR2

99

S19P3

3

Complete

95

V₃₋₂₃ (vh26, 30p1, DP-47)

S4P23

3

Complete

86

FL, anti-DNA, RF

4,5,30,35,40,41

S10P19^a

3

Complete

93

S14P5

3

Complete

94

S16P4

3

Complete

92

S16P5

3

Complete

95

S1-4P4

3

CDR2

98

S3P6^a

3

CDR2

87

89% homology to anti-TG antibody

42

V₃₋₄₉

S6P21^a

3

CDR 2

97

—

5

V₃₋₅₃ (DP-42)

S7P13

3

Complete

86

—

4,5

V₃₋₀₇ (DP-54)

S10P18

3

CDR2

92

—

4,5

V₃₋₄₈ (DP-51)

S17P3

3

FR1

81

—

4,5

V₃₋₂₁ (DP-77)

S20P4

3

Complete

93

—

4,5

V₄₋₃₁ (DP-65)

S1P1^a

4

Complete

85

CLL

4,5,38

V₄₋₀₄ (DP-70)

S2P1^a

4

CDR2

80

—

4,5

V₄₋₅₉ (4.11, DP-71, 58p2)

S4P11^a

4

Complete

91

FL

4,5,30,43

V₄₋₃₉ (DP-79)

S20P2

4

Complete

99.7

—

4,5

V₅₋₅₁ (DP-73)

S15P5

5

Complete

90

TS Ab

4,5,44

V₆₋₀₁ (DP-74)

S1-3P1

6

FR3

92

FL

4,5,30