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Fig. 5 | Molecular Medicine

Fig. 5

From: Induction of the Chemokine β Peptides, MIP-1α and MIP-1β, by Lipopolysaccharide Is Differentially Regulated by Immunomodulatory Cytokines γ-IFN, IL-10, IL-4, and TGF-β

Fig. 5

Costimulation of macrophages with IL-4 does not inhibit the release of MIP-1β by LPS-stimulated macrophages in vitro at concentrations that completely shut off LPS-induced production of both MIP-1α and TNF-α. (A, B) Macrophages (1 × 106 cells) were incubated with the indicated amount of IL-4 either in the absence (solid bars) or presence of various concentrations of LPS. Culture medium was collected at 18 hr and the MIP-1α (A) and MIP-1β (B) content quantified by separate ELISAs. Data are from a representative experiment (of 2) and are expressed as the mean ± SD of values obtained from duplicate macrophage stimulations.

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Molecular Medicine

ISSN: 1528-3658