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Fig. 5 | Molecular Medicine

Fig. 5

From: The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical Relevance

Fig. 5

Viral interference with TAP function. The major mechanisms of viral proteins interfering with TAP function are schematically represented. ICP47 (HSV) blocks the peptide-binding site of TAP, US6 (CMV) induces conformational changes of TAP by binding to it in the ER lumen, and Ad E3gp19K inhibits tapasin binding to TAP, thereby blocking the association of MHC class I HC with TAP. PRV interferes with TAP, thereby inhibiting its function; the exact mechanism is unknown.

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Molecular Medicine

ISSN: 1528-3658