The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical Relevance

Table 1 TAP downregulation in lesions and cell lines derived from human tumors of distinct histology

	Downregulation of Expression (%)
		Primary Lesions			Cell Lines
Tumor Type	Samples (n)	TAP1	TAP2	Samples (n)	TAP1	TAP2
Breast carcinoma	63	13–44	21	ND	ND	ND
SCLC	93	38	ND	6	100	100
Colon carcinoma	81	14	ND	5	32	23
RCC	70	52	ND	19	79	74
Cervical carcinoma	76	49	ND	7	0	0
Melanoma	53	31	16	9	33	57

ND, not determined.
Results are expressed as percent downregulation of TAP1 and TAP2 expression when compared to respective controls and have been recently summarized by Seliger et al. (23).

ISSN: 1528-3658