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Fig. 1 | Molecular Medicine

Fig. 1

From: In Vivo Gene Transfer to Dopamine Neurons of Rat Substantia Nigra via the High-Affinity Neurotensin Receptor

Fig. 1

Uptake of propidium iodide-labeled NT-polyplex by dopamine neurons of the substantia nigra. (A, B, and C) Merged images of FITC-immunolabeled dopamine neurons (green) and propidium iodide-labeled NT-polyplex (red). (D) Merged image of FITC-immunolabeled glial cells (green) and propidium iodide-labeled NT-polyplex. (A) is 1-µm optical section that shows the uptake of propidium iodide-labeled NT-polyplex by dopamine neurons. (B) is 1-µm optical section that shows the blockade of the neuronal uptake of propidium iodide-labeled NT-polyplex by 0.45 M sucrose solution. (C) is a z-series projection that shows the absence of propidium iodide-labeled NT-polyplex internalization in dopamine neurons in presence of 1 µM SR-48692. (D) is a z-series projection that shows the inability of glial cells to internalize propidium iodide-labeled NT-polyplex.

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Molecular Medicine

ISSN: 1528-3658