Fig. 7
Effect of dominant negative ER on T47D cell growth in vivo. (A) The effect of dominant negative ER on tumor formation by T47D cells in nude mice. T47D cells were infected with adenoviral vectors and injected into nude mice as described in Materials and Methods. Tumor volume was measured after 3 weeks. Each bar represents the mean ± standard error (S.E.) of tumor volumes; numbers in parenthees indicate the number of tumors formed per 6 injection sites. The difference between uninfected and AdGal groups was not significant (p > .05). (B) Anti-tumor effect of dominant negative ER on pre-established T47D cell tumors in nude mice. Tumors were injected with adenoviral vectors as described in Materials and Methods. The tumor sizes were measured twice a week for 3 weeks. Tumor volume is presented as mm3, mean ± S.E. for each treatment group. Points showing a statistically significant difference from AdGal are marked (#: α [experimentwise error rate] < 0.05; *: α < 0.01).