Fig. 1
From: ApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury
Increased blood brain barrier permeability in apoE −/− mice. 8 weeks old WT and apoE−/− mice were injected with Evans blue dye. Three hours later the mice were sacrificed and the dye extracted from the brains (injury −). Alternatively, the mice were subjected to cold injury of the cortex seven days prior to dye injection (injury +). ApoE−/− mice had significantly increased BBB permeability to Evans blue dye bound to albumin and this difference from WT was accentuated after brain injury. Optical density of brains obtained from animals without Evans blue injection was negligible.