Hypertension Exacerbates Coronary Artery Disease in Transgenic Hyperlipidemic Dahl Salt-sensitive Hypertensive Rats

Table 1 Lipid profile of control and Tg53 rats on regular (0.4% NaCl) and low salt (0.008% NaCl) diets

Groups	TC		TG	ApoB	VLDL size		LDL size	HDL size
4 m nonTg-reg (n)	146.2 ± 34.0 (11)		143.5 ± 49.9 (11)	26.2 ± 8.6 (11)	34.5 ± 5.8 (145P)		24.6 ± 2.7 (95P)	15.4± 1.6 (5p)
4 m Tg53-reg (n)	386.0 ± 53.0^# (6)		2993.0 ± 811.3^# (6)	483.5 ± 162.^# (6)	50.2 ± 20.1* (224p)		23.4 ± 3.0* (54p)	15.1 ± 1.9^NS (33p)
10 m Tg53-lsd (n)	456.4 ± 112.4 (7)		3454.0 ± 1198 (7)	nd	nd		nd	nd
Analysis of lipoprotein subclass:
Groups (n)	VLDLc	IDLc	LDLc	HDLc	VLDLtg	IDLtg	LDLtg	HDLtg
4 m nonTg-reg (11)	8.5 ± 3.0	5.8 ± 2.6	54.0 ± 16.1	78.7 ± 22.3	80.0 ± 33.7	27.0 ± 11.4	19.6 ± 9.6	17.1 ± 8.6
4 m Tg53-reg (6)	324.1 ± 54.1^#	24.1 ± 13.2^#	22.3 ± 9.1^#	15.3 ± 11.5^#	2691.0 ± 738.4^#	143.5 ± 108.4^#	97.0 ± 44.3^#	60.5 ± 32.4^#
10 m Tg53-lsd (7)	400.7 ± 93.3	25.7 ± 9.0	19.6 ± 9.2	10.5 ± 10.0	3105.0 ± 1002	189.8 ± 162.1	87.5 ± 66.5	71.4 ± 59.6
Groups (n)	%VLDLc	%IDLc	%LDLc	%HDLc	%VLDLtg	%IDLtg	%LDLtg	%HDLtg
nonTg-reg (11)	5.8 ± 2.0	4.0 ± 1.5	37.1 ± 7.7	53.4 ± 8.1	54.7 ± 8.3	19.7 ± 7.6	13.4 ± 2.6	12.4 ± 5.2
Tg53-reg (6)	84.0 ± 7.8^#	6.2 ± 3.2*	5.8 ± 2.4^#	3.9 ± 2.7^#	90.0 ± 4.6^#	4.6 ± 2.9^#	3.3 ± 1.5^#	2.1 ± 1.2^#
Tg53-lsd (7)	88.2 ± 2.2	5.5 ± 2.2	4.1 ± 1.3	2.2 ± 1.5	90.7 ± 3.8	5.1 ± 3.2	2.3 ± 1.2	1.9 ± 1.2

#, ANOVA P < 0.0001; *, t-test P < 0.05; NS, not significant; lipid profile presented as mean ± s.d. mg/dl; nd, not done; non-Tg, non-transgenic Dahl S rat controls on regular (0.4% NaCl) rat chow; Tg53-reg, Tg53 rats on regular rat chow; Tg53-lsd, Tg53 rats on low salt (0.008% NaCl) diet. ApoB, apolipoprotein B; c, cholesterol in subclass; HDL, high density lipoprotein; IDL, intermediate density lipoprotein; LDL, low density lipoprotein; n, number of rats or particles (p); TC, total plasma cholesterol; TG, total plasma triglyceride; tg, triglyceride in subclass; VLDL, very low density lipoprotein.

ISSN: 1528-3658