Table 2 Phenotype component scale of coronary artery disease
Coronary Artery Disease Phenotype | 6m nonTg (0.4% NaCl) n = 6 | 6m Tg53 (0.4% NaCl) n=6 | 10m Tg53 (0.008% NaCl) n=7 | End-stage Tg53 (0.4% NaCl) n=7 |
|---|---|---|---|---|
ACS-EQUIVALENT | ||||
overt cardio-resp distress | (−) | − | − | + |
myocardial infarction | (−) | + | + | +++ |
signs of heart failure | (−) | (−) | (−) | + |
LESION PARAMETERS (PROXIMAL) lesion occlusion >75% | (−) | (−) | (−) | + |
vessel remodeling at lesion site | (−) | (−) | (−) | + |
intimal foam cells | (−) | + | ++ | +++ |
extracellular lipid | (−) | (−) | + | +++ |
smc in intimal lesion | (−) | (−) | + | + |
lesion-site decreased smc in media | (−) | (−) | + | + |
monocyte adhesion | (−) | + | + | + |
adventitial inflammation | (−) | + | + | + |
neutrophil adhesion | (−) | (−) | (−) | + |
calcification | (−) | (−) | (−) | (−) |
disrupted IEL | (−) | (−) | (−) | + |
neovessels | (−) | (−) | (−) | + |
hemorrhage | (−) | + | + | +++ |
thrombosis | (−) | + | ++ | +++ |
erosion | (−) | (−) | + | + |
rupture | (−) | (−) | (−) | + |
lesion apoptosis | nt | nt | + | +++ |
macrophage MMP3/TIMP3 ratio >1 | nt | nt | + | |
model score | 0/19 | 6/19 | 11/21 | 20/21 |