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Table 1 Effects of leukotriene E 4 on number of histamine H 1 receptors in human peripheral blood monocytes

From: Cysteinyl Leukotrienes Mediate Histamine Hypersensitivity Ex Vivo by Increasing Histamine Receptor Numbers

Volunteer

Receptors/cell before stimulation

Receptors/cell after stimulation

K d (nM)

A

54207

105403

6

B

45173

90345

6

C

22586

48184

5.5

D

12046

57219

6.7

E

2259

9787

3

  1. Blood was isolated from five healthy volunteers (A–E) and monocytes were prepared. These cells were stimulated with leukotriene E4 (100 ng/ml) for 15 min. Scatchard analysis was performed to determine number of receptors per cell as described in Materials and Methods.
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Molecular Medicine

ISSN: 1528-3658