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Fig. 1. | Molecular Medicine

Fig. 1.

From: Association of Severe Noncerebral Plasmodium falciparum Malaria in Brazil With Expressed PfEMP1 DBL1α Sequences Lacking Cysteine Residues

Fig. 1.

DBL-1α var sequences expressed in patients with severe malaria revealed predominantly expressed sequences lacking 1–2 cysteine residues. (A) Maximum likelihood phylogenetic tree of var genes based on the N-terminal segment of DBL1α. The value of the gamma distribution with shape parameter α was 1.6315. Sequences preferentially (closed boxes) and rarely (open boxes) expressed in each isolate are indicated. Abbreviations: AF, accession numbers of GenBank from Sudanese sequences; G, sequences obtained from parasites of severe malaria; NG, sequences obtained from parasites of mild malaria. The gray area represents the group of sequences lacking 1–2 cysteine residues. (B) Alignment of 67 deduced amino acid sequences from the cysteine-rich region of DBL1α var sequences from Brazilian patients with severe malaria (G), mild malaria (NG), and patients from Sudan (AF). The region of DBL1α domain lacking 1–2 cysteine residues from 11 sequences is boxed.

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Molecular Medicine

ISSN: 1528-3658