The Dual AngII/AVP Receptor Gene N119S/C163R Variant Exhibits Sodium-Induced Dysfunction and Cosegregates With Salt-Sensitive Hypertension in the Dahl Salt-Sensitive Hypertensive Rat Model

Table 2 AngII and AVP binding parameters of Dahl S and Dahl R AngII/AVP receptors

AngII/AVP Receptor	K_H AngII (nM)	B_MAX(fmol 10⁻⁶ cells)	K_L AngII (nM)	B_MAX (fmol 10⁻⁶ cells)	K_H AVP (nM)
Dahl S	0.88 ± 0.38	1.50 ± 0.54	8.90 ± 2.31	10.40 ± 2.18	0.30 ± 0.04
Dahl R	4.30 ± 0.99	16.40 ± 2.72	ND	ND	0.70 ± 0.08

Scatchard analysis (RADLIG, Version 4 Program, McPherson) of the [³H]-AVP and ¹²⁵I-labeled AngII saturation curves (Fig. 3) was performed. K_H. high affinity (nM ± error); K_L, low affinity (nM ± error); ND, nondetected.

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