Table 3 Confirmed LYST interactions identified by reverse yeast two-hybrid screens with a fetal brain prey library

190–1056

14-3-3τ (X56468)

Vesicular trafficking and signal transduction

290

2

356

2

14-3-3β (HS1) (X57346)

Signal transduction

465

2

Calmodulin (D45887)

Ca²⁺-binding, vesicular trafficking and signal transduction

479

1

Estrogen receptor-related

Signal transduction: hormone nuclear

protein, ERR1 (X51416)

receptor and transcription factor

939

4009–4821

14-3-3τ (X56468)

Vesicular trafficking and signal transduction

290

1

6586–7449

Importin β-subunit p ](L38951) Imogen 38 (Z68747)

Nuclear protein transport; has ARM and HEAT repeats Pancreas β-cell protein (secretory granule/

1970

¹

mitochondrion)

473

1

DiGeorge syndrome-1, DGS1 (L77566)

Novel gene from DGS critical region (22q11)

454

1

Norbin, KIAA0607 (AB011179) LIP1, novel (AF141337)

98% I, 98% S to rat norbin (AB006461); neurite outgrowth 66% I, 85% S, 35 amino acids, human

1462

1

TCP10A protein

1

1

(U03399)

5

LIP2, novel (AF141338)

40% I, 56% S, 110 amino acids, bacterial ribosomal protein

1

1

L17 (M26414)

10

1

21

1

LIP4, novel (AF141340)

62% I, 73% S, 89, human hnRNP-E2 (X78136)

496

1

LIP5, novel (AF141341)

35% I, 61% S, 131, C. elegans T23G11.7 (Z81130)

48

1

LIP6, novel (AF141342)

92% I, 93% S, 139, viral protein NS2-3

(U43603)

1

2

LIP7, novel (AF141343)

30% I, 59% S, 81, human TCP10A protein (U03399)

1

2

LIP8, novel (AF141344)

63% I, 63% S, 21, rabbit KAP4L protein (X80035)

1

2

9037–9585

LIP3, novel (AF141339)

72% I, 83% S, 172, rat Zn finger protein Roaz (U92564)

345

1

9502-10590

Atrophin-1 (U23851)

Mutated in dentatorubral pallidoluysian

(BEACH

atrophy (DRPLA)

2659

1

domain)

Embryonic-Fyn-substrate 1, EFS1 (AB001466)

Signal transduction

1664

OPA-containing protein (AF071309)

Unknown function

5262

¹

M4 hnRNP (L03532)

RNA-binding, heterogeneous nuclear ribonucleoprotein

782

1

LIP3, novel (AF141339)

72% I, 83% S, 172, Zinc finger protein Roaz (U92564)

345

1

LIP9, novel (AF141345)

61% I, 75% S, 180, RNA binding protein etr1 (U16800)

138

1

10576–11611

Casein kinase

Phosphorylation: vesicular trafficking

(WD-40

II β-subunit (M30448)

and signal transduction

60

1

domain)

LIP6, novel (AF141342)

92% I, 93% S, 139, viral nonstructural protein NS2-3

1

1

(U43603)

5

¹