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Fig. 2 | Molecular Medicine

Fig. 2

From: Cholesterol Depletion Blocks Redistribution of Lipid Raft Components and Insulin-Mimetic Signaling by Glimepiride and Phosphoinositolglycans in Rat Adipocytes

Fig. 2

Effect of cholesterol depletion on translocation of Gce1 and pp59Lyn from hcDIGs to lcDIGs. Isolated rat adipocytes were incubated in the absence or presence of 10 mM mβCD (50 min, 30°C) and subsequently in the absence (control) or presence of 3 µM PIG41 or 30 µM glimepiride (Am). hcDIGs (h) and lcDIGs (l) were prepared and immunoblotted for pp59Lyn and caveolin-1 (IB) or photoaffinity labeled for Gce1 (PL). The figure shows representative phosphor- and chemiluminescent images repeated three times.

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Molecular Medicine

ISSN: 1528-3658