Skip to main content

Table 4 Binding motif in HLA-A*201 binding peptides

From: Methods for Prediction of Peptide Binding to MHC Molecules: A Comparative Study

  

Peptides

Peptide Set

Data Set

Basic Motif*

Extended Motif‡

T-cell epitopes

Initial

75 (61%)

114 (92.7%)

 

Extended

75 + 28 (56.3%)

114 + 55 (92.3%)

Naturally processed

Initial

13 (39.4%)

33 (100%)

 

Extended

13 + 14 (47.4%)

33 + 17 (87.7%)

Poly-Ala

Initial

36 (81.8%)

43 (97.7%)

Other synthetic

Initial

80 (50.3%)

138 (86.8%)

Nonbinders

Initial

23 (2.9%)

243 (30.1%)

  1. *Basic motif defined as x(L,M)xxxxxx(V,L).
  2. ‡Extended motif defined as x(T,A,V,I,L,M)xxx(T,A,M,J,V,L)
Back to article page

Molecular Medicine

ISSN: 1528-3658