Insulin-Like Growth Factor Family and Combined Antisense Approach in Therapy of Lung Carcinoma

Table 4 M6-P/IGF-IIR protein immunohistochemical test in IGF-II negative and IGF-II positive tumors

Patient	Tumor Subtype	TNM Stage	IGF-IR*	IGF-IR mRNA*	M6-P/IGF-IIR*⁺
IGF-II	nagative	tumors
1	AC	I	0	−	+++
2	AC	I	0	−	++
5	AC	II	0	−	++
9	AC	II	0	−	+++
10	AC	II	0	−	+
31	LCA	IIIa	0	−	+++
67	SCC	IIIa	++	+	++
68	SCC	IIIa	0	−	+++
69	SCC	IIIa	0	−	+++
IGF-II	positive	tumors
3	AC	I	++	+	0
4	AC	II	++	+	0
6	AC	II	+++	+	++
7	AC	II	++	+	++
8	AC	II	+++	+	+
11	AC	II	++	+	++
12	AC	II	+	+	+++
13	AC	II	+++	+	+
14	AC	IIIa	+++	+	+
15	AC	IIIa	++	+	0
16	AC	IIIa	+++	+	0
30	LCA	IIIa	+++	+	+
39	SCC	IIIa	+++	+	0
60	SCC	IIIa	+++	+	0
61	SCC	IIIa	++	+	++
62	SCC	IIIa	+++	+	+
63	SCC	IIIa	++	+	+
64	SCC	IIIa	+++	+	0
65	SCC	IIIa	+++	+	+

*mRNA positive (+) and negative (−) samples
*^‡0 negative tumors; +, ++, + + + are weakly positive ++, moderately positive, +++ strongly positive tumors.

ISSN: 1528-3658