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Table 3 Molecular markers with a postulated prognostic significance in NE tumors

From: Genetic and Molecular Coordinates of Neuroendocrine Lung Tumors, with Emphasis on Small-cell Lung Carcinomas

Proteins Comments References
β-catenin Its cytoplasmic overexpression has negative prognostic role in SCLCs 98
Bcl-2 Arguable prognostic role in SCLCs/adverse prognosis in large NE tumors 121123,125
bFGF Favorable prognostic significance in SCLCs 210
CD44 CD44v6 is correlated with tumor aggressiveness in NE tumors 100
c-erbB-2 Poor prognosis in advanced SCLCs 79
c-myc Negative prognostic value in SCLCs 160,163
MMP-3 Unfavorable prognostic significance in SCLCs 185
MMP-11 Adverse prognosis in SCLCs 185
MMP-14 Negative predictive value in SCLCs 185
L-myc Correlated with variant SCLC/ambiguous predictive value 32,160,163
Metallothionein Adverse prognostic significance in SCLCs 134
N-myc Correlated with variant SCLC/ambiguous predictive value 32,169,163
PAI-2 Favorable prognostic value in NE tumors 188
p53 Arguable prognostic role in NE tumors 60,126,133,134
P-glycoprotein Its expression has negative prognostic role in SCLCs 255257
pRb LOH is related to a poor clinical outcome in NE tumors 49
Telomerase Adverse prognostic significance in NE tumors 183
TIMP-1 Associated with better response to therapy 185
Topo II a Its elevation correlates with adverse prognosis in SCLCs 121
VEGF Related to chemoresistance and adverse prognosis in SCLCs 206,207
  1. Abbreviations: SCLC, Small-cell lung cancer; NE, neuroendocrine; LOH, Loss of heterozygosity.