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Fig. 3 | Molecular Medicine

Fig. 3

From: Molecular Evidence-Based Use of Bone Resorption-Targeted Therapy in Prostate Cancer Patients at High Risk for Bone Involvement

Fig. 3

Illustration of the initial steps implicated in the formation of bone metastasis. (A) Dissemination and survival of prostate cancer cells in the peripheral blood. (B) Dissemination of tumor cells into the metabolically active red bone marrow (micrometastasis stage). (C) Activation of bone resorption, which enables the migration of tumor cells into bone matrix and the establishment of macrometastasis in bones.

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Molecular Medicine

ISSN: 1528-3658