Table 2 Human histone deacetylases
From: Histone Acetylation Modifiers in the Pathogenesis of Malignant Disease
Family | Members | Alternate Symbols | Cytogenetic Position | Histone Preference (K: lysine specificity) | HD type | References | ||||
|---|---|---|---|---|---|---|---|---|---|---|
H2A | H2B | H3 | H4 | HDA | HDB | |||||
RPD3 orthologs (class I HDACs) | HDAC1 HDAC2 HDAC3 | — | 1p34.1 6q21 5q31.1 | + | + | + K5,12 16(⋯) | + K9,14, (⋯) | + | (28,63,66, 70,74,75, 80–83,85, 88,195,234, 242,247) | |
HDA1 orthologs (class II HDACs) | HDAC4 HDAC5 HDAC6 HDAC7 | HDAC-A NY-CO-9 — MTR | 2q37.2 17 × 7p15-p21 | + | + | + | + | + | (28,87,88, 92,248) | |