Fc-Receptor-Mediated Intracellular Delivery of Cu/Zn-superoxide Dismutase (SOD1) Protects Against Redox-Induced Apoptosis Through a Nitric Oxide Dependent Mechanism

Table 4 Intracellular delivery of Bo-SOD1 by immune complexes promote the antioxidant armature in interferon- γ -treated macrophages

Interferon-γ-treated cells (2 × 10⁶ cells/ml) were challenged overnight by Bo-SOD1 IC (20 µg of anti-Bo-SOD1 and 10 µg of Bo-SOD1) and/or of 1 mM L-NAME. After extraction of total intracellular proteins, antioxidant enzymes activities and GSH measurements were done as described in Materials and Methods. Data are the mean ± SD (triplicate samples) of one representative experiment out of four.

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