Table 1 Glycoproteins of BHV-1
From: BHV-1: New Molecular Approaches to Control a Common and Widespread Infection
Protein | Gene | Location | ID | MW | Gly | Function | Reference |
|---|---|---|---|---|---|---|---|
gI = gB | UL27 | env | E + | 130 74 55 (101) | N | Heterodimer Binding to heparin-like factors Attachment, entry, fusion, cell to cell spread | 72, 57 |
gII = gH | UL22 | env | E − | 108 (88) | N | Entry, cell-to-cell spread, egress | 188, 189 |
gIII = gC | UL44 | env | NE + | 91 (54) | N, O | Hemagglutinin (virulence factor) Binding to heparin-like factors and to C3b | 54, 57, 66, 190 |
gIV = gD | US6 | env | CE + | 71 (45) | N, 0 | Binding to mannose-6-phosphate receptors Entry, cell-to-cell spread | 57, 59, 52, 50, 51 |
gE | US8 | env | NE + | 92 (61) | N | Neuroinvasiveness Fc receptor (with gI) Cell-to-cell spread | 53, 154, 173, 179 |
gX = gG | US4 | Secreted | NE − | (65) | N, O | Function unknown | 191, 192 |
gK | UL53 | env | ? − | (35) | N | Syncytium formation | 193 |
gI | US7 | env | NE − | (40) | ? | Neuroinvasiveness Binding to Fc receptor (with gE) Cell-to-cell spread | 49 |
gM | UL10 | env | NE − | (43) | N | Spread in CNS, membrane penetration | 194 |
gL | UL1 | Secreted | E − | (17) | O | Conserved Entry, cell-to-cell spread | 195 |