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Table 2 Comparison of absolute numbers of CD3, γδ, and Vγ9/Vδ2 cells in peripheral blood and CSF of children affected by TBM and control subjects

From: Predominance of Vγ9/Vδ2 T Lymphocytes in the Cerebrospinal Fluid of Children with Tuberculous Meningitis: Reversal after Chemotherapy

Source

Absolute Number/µl ± S.E.

CD3+ Cells

Total γδ+ Cells

Vδ2+ Cells

TBM patients

   

CSF

167 ± 24*

6.7 ± 1.9* (4)a

5.9 ± 0.9* (88)b

PBMC

1580 ± 268

78 ± 19 (4.9)a

56 ± 14 (72)b

Controls

   

CSF

20 ± 5*

0.7 ± 0.3* (3.4)a

0.2 ± 0.1* (29)b

PBMC

1625 ± 418

84 ± 26 (5.2)a

60 ± 14 (71)b

  1. PBMC and CSF samples were analyzed using two- and three-color flow cytometry as described in Materials and Methods. The differences in CSF values between TBM patients and control children were all significant (*p < 0.001).
  2. aThe percentage of total γδ+ cells, within CD3+ cells, is shown in parentheses.
  3. bThe percentage of Vδ2+ T cells, within total γδ+ cells, is shown in parentheses.
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Molecular Medicine

ISSN: 1528-3658