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Fig. 5 | Molecular Medicine

Fig. 5

From: Neurotrophic Factors Regulate Cathepsin S in Macrophages and Microglia: A Role in the Degradation of Myelin Basic Protein and Amyloid β Peptide

Fig. 5

Time-course analysis of bFGF-induced cathepsin S protease activity in macrophages. RAW macrophage cells were treated with various doses of bFGF for 24 (solid bars) or 48 hr (shaded bars) and cathepsin S protease activity was measured in cells (A), and C.M. (B), utilizing the fluorogenic substrate Z-FR-AMC as described in Materials and Methods. Data represent mean ± SEM of measured E64-inhibitable cathepsin S activity of triplicate samples each with triplicate determinations. Cathepsin S activity is expressed in fluorescent units and activity detected in the absence of bFGF treatment is taken as control.

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Molecular Medicine

ISSN: 1528-3658