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Table 1 Sensitivity of human PC3 prostate cancer cells and mouse P815 mastocytoma cells to hydrogen peroxide

From: Nonredundant Antioxidant Defense by Multiple Two-Cysteine Peroxiredoxins in Human Prostate Cancer Cells

Cell

Experiments (No.)

LD50 (10−6 M)*

p †

P815

2

44 ± 1.4

0.0285

PC3 parental

12

244 ± 102

n/a

PC3 vector only

22

326 ± 152

0.1041

PC3 vector + BSO

9

102 ± 60

0.0016

pcASPrx 1

10

102 ± 21

0.0024

pcASPrx 2

8

59 ± 8

0.0002

pcASPrx 3

8

84 ± 26

0.0016

pcASPrx 4

9

232 ± 81

0.7891

  1. *Values are means ± SD for the interpolated doses that were lethal to 50% of the cells, where each datum consists of an LD50 derived from an independent experiment.
  2. †Comparison to results for PC3 cells (ANOVA and Kruskal-Wallis analysis).
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Molecular Medicine

ISSN: 1528-3658